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Evaluation of Shiga toxin 2e-specific chicken egg yolk immunoglobulin: Production and neutralization activity.

Posted by on in 2014
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Abstract

Chicken egg yolk immunoglobulin (IgY) against Shiga toxin 2e (Stx2e), a major cause of swine edema disease, was prepared to evaluate its possible clinical applications. The titer of Stx2e-specific IgY in egg yolk derived from three chickens that had been immunized with an Stx2e toxoid increased 2 weeks after primary immunization and remained high until 90 days after this immunization. Anti-Stx2e IgY was found to neutralize the toxicity of Stx2e by reacting with its A and B subunits, indicating that IgY is a cost-effective agent to develop for prophylactic foods or diagnosis kits for edema disease.

© 2014 The Societies and Wiley Publishing Asia Pty Ltd.

KEYWORDS:

Shiga toxin 2e; chicken IgY; edema disease

PMID:
 
25175999
 
[PubMed - in process]
Last modified on