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Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils.

Posted by on in 2016
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Thomsen K1Christophersen L1Jensen PØ1Bjarnsholt T1,2Moser C1Høiby N1,22016. Hum Vaccin Immunother. 12(7):1690-9. doi: 10.1080/21645515.2016.1145848. Epub 2016 Feb 22.

1
 Department of Clinical Microbiology , Rigshospitalet, Copenhagen University Hospital , Copenhagen , Denmark.
2
Department of Immunology and Microbiology , Faculty of Health Sciences University of Copenhagen , Copenhagen , Denmark.

 

Abstract

Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.

KEYWORDS:

IgY; cystic fibrosis; phagocytosis; pseudomonas aeruginosa

PMID:
 
26901841
 
PMCID:
 
PMC4964812
 
DOI:
 
10.1080/21645515.2016.1145848
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