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SiRNA Useful to Suppress expression of eIF-5A1 *

Posted by on in 2011
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Thompson, J. E., Galton, B. C., Taylor, C., Boone, A., Heikkila, E.,  Cliche, D., Culp-stewart, S.,
Flanagan, J. G., Senchyna, M. 2011. US Patent Application 20110098460

Abstract:

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.

*Note:  The custom IgY (directed against the eIF-5A) and the HRP-Anti-IgY used in this publication were manufactured by Gallus Immunotech Inc.

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