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Amphibians have immunoglobulins similar to ancestral IgD and IgA from Amniotes.

Posted by on in 2016
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Estevez O1Garet E2Olivieri D3Gambón-Deza F4. 2016. Mol Immunol. 69:52-61. doi: 10.1016/j.molimm.2015.11.005. Epub 2015 Dec 10.

  • 1Area de Inmunología, Facultad de Biología, University of Vigo, 36310 Vigo, Spain. Electronic address: olivieri@ei.uvigo.es.
  • 2Area de Inmunología, Facultad de Biología, University of Vigo, 36310 Vigo, Spain.
  • 3School of Computer Science, University of Vigo, Ourense 32004, Spain.
  • 4Servicio Gallego de Salud (SERGAS), Unidad de Inmunología, Hospital do Meixoeiro, 36210 Vigo, Spain. Electronic address: fgambon@gmail.com.

Abstract

We studied the immunoglobulin genes from either the genomes or RNAs of amphibians. In particular, we obtained data from one frog genome (Nanorana parkeri) and three transcriptomes of the Caudata order (Andrias davidianus, Notophthalmus viridescens and Cynops pyrrhogaster). The species N. parkeri, N. viridescens and C. pyrrhogaster have two IgD genes, while Andrias davidianus has three such genes. The three Caudata species have long IgD immunoglobulins similar to IgD of reptiles, and could be an ancient relic from the common ancestor of IgD of all mammals and reptiles. We also found two IgA isotypes. The results suggest that one of the IgA may be the ancestor of IgA in crocodiles and birds, while the other could be the ancestor IgA found in mammals. These results provide information that could help understand the evolution of immunoglobulins in terrestrial vertebrates.

Copyright © 2015 Elsevier Ltd. All rights reserved.

KEYWORDS:

Amphibian immunoglobulins; Evolution of immunoglobulins

PMID:
 
26675067
 
[PubMed - in process]
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